Obstetrics Research Today is a free monthly online journal that collates and summarizes the latest research about Obstetrics, including details on caesarean delivery, child birth, labour. | ||||||||
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N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective randomized controlled study.Elnashar A, Fahmy M, Mansour A, Ibrahim K Department of Obstetrics and Gynecology, Benha University Hospital, Benha, Egypt. elnashar53@hotmail.com <elnashar53@hotmail.com> OBJECTIVE: To compare the effect of N-acetyl cysteine and metformin on hormonal profile (insulin and T) and ovulation rate in women with clomiphene citrate-resistant polycystic ovary syndrome. DESIGN: Prospective randomized controlled study. SETTING: Department of obstetrics and gynecology in a university hospital in Egypt. PATIENT(S): Sixty-one infertile women with clomiphene citrate-resistant polycystic ovary syndrome were assigned randomly to receive either metformin (1,500 mg/d) or N-acetyl cysteine (1.8 g/d) for 6 weeks. INTERVENTION(S): Hormonal profile was determined before and after the course of treatment. Folliculometry was performed to assess ovulation. MAIN OUTCOME MEASURE(S): Ovulation rate and insulin and T changes. RESULT(S): In the metformin group, there was a significant decrease in the fasting glucose, fasting insulin, and total T. In the N-acetyl cysteine group, there was no significant difference in the fasting glucose or fasting insulin and there was a significant decrease in total T. There was no significant difference in the fasting glucose-fasting insulin ratio in both groups. In the metformin group, the rate of ovulation was 51.6% (16/31), vs. 6.7% (2/30) in the N-acetyl cysteine group, which was statistically significant. CONCLUSION(S): Metformin alone is an effective drug in inducing ovulation in clomiphene citrate-resistant polycystic ovary syndrome, whereas N-acetyl cysteine alone is not. Further large studies are required to confirm our results. Published 13 August 2007 in Fertil Steril, 88(2): 406-9.
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